Hypoxia Selectively Activates the CREB Family of Transcription Factors in theIn VivoLung
نویسندگان
چکیده
منابع مشابه
The ATF/CREB Family of Transcription Factors in Breast Cancer
Transcription factors are proteins that bind DNA and either promote or block gene transcription. The activating transcription factor/cyclic AMP response element binding (ATF/CREB) family of transcription factors are involved in various cellular processes, including cell stress responses, cell survival, and cell growth. In this chapter, we will first give an overview of the transcriptional regul...
متن کاملTargeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.
The cAMP response element binding protein (CREB) has been implicated as a key regulator in the transcriptional control of many genes. To assess the functional importance of CREB in vivo and its role in development, we used gene targeting to generate mice with a disruption of the CREB gene. Homozygous mutant mice appeared healthy and exhibited no impairment of growth or development. In this repo...
متن کاملFunction and Regulation of CREB Family Transcription Factors in the Nervous System
CREB and its close relatives are now widely accepted as prototypical stimulus-inducible transcription factors. In many cell types, these factors function as effector molecules that bring about cellular changes in response to discrete sets of instructions. In neurons, a wide range of extracellular stimuli are capable of activating CREB family members, and CREB-dependent gene expression has been ...
متن کاملAMP-activated protein kinase phosphorylates transcription factors of the CREB family.
AMP-activated protein kinase (AMPK) has been identified as a regulator of gene transcription, increasing mitochondrial proteins of oxidative metabolism as well as hexokinase expression in skeletal muscle. In mice, muscle-specific knockout of LKB1, a component of the upstream kinase of AMPK, prevents contraction- and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)-induced activati...
متن کاملThe HIV-1 matrix protein p17 activates the transcription factors c-Myc and CREB in human B cells.
The human immunodeficiency virus matrix protein p17 plays a critical role in many steps of the virus life cycle. In addition, p17 displays biological activities outside infected cells. Indeed, virus-neutralizing antibodies against p17 in plasma of infected patients correlate with slower disease progression, and p17 has been shown to interact with an as yet unidentified cell surface receptor exp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2008
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.200712-1890oc